LiverTrio+ was created by a Veterinarian and a Pharmacist. As medical practitioners in the veterinary field we came to realize the lack of an AFFORDABLE and COMPREHENSIVE liver supplement.
LiverTrio+ chew tablets combine S-Adenosylmethionine (SAMe), L-Glutathione, Silybin Phosphatidylcholine Complex (SPC) and Silybin A+B (as part of SPC). This combination aims to deliver a comprehensive liver supplement for dogs and cats.
Chronic liver disease is characterized in most cases by a significant decrease in L- glutathione. L- glutathione is a molecule found in the liver that protects it from oxidative damage.2,3,4
During liver disease dogs and cats commonly show low glutathione values with cats having a higher risk than dogs for low liver glutathione values.2
Proper liver function is key to maintain your pet healthy and strong. In many cases, liver function is affected by external factors out of our control such as disease or congenital factors. LiverTrio+ can help your pet and with your help, regain some of that control back.
LiverTrio+ ‘s combination of SAMe, SPC and Glutathione in an easy to chew tablet form, brings together three compounds that have been shown to help improve liver health and brain health. LiverTrio+ should aid in restoring your pet’s liver to a proper functioning state. This way your pets can continue to live a long, happy and healthy life. 1,4,5,6,7,8,9,10
SAMe oral administration has been shown to increase liver levels of L- Glutathione. 5 By increasing liver levels of L- Glutathione, SAMe initiates a cascade of processes that may help protect liver cells from death. Decreased liver cell death, leads to increased liver cell regeneration which results in improved liver function and overall improved health during LiverTrio+ supplementation.
In addition, SAMe has been shown to contribute to brain health by its role in increasing glutathione levels.12 There are current several studies furthering research on how glutathione influences brain health.
Silybin Phosphatidylcholine Complex (SPC)
SPC is the most potent of the flavonoids in milk thistle. In Vivo and In Vitro studies have shown SPC has liver protective properties. SPC has been shown to decrease cell oxidative damage. This in turn results in SPC contributing to the preservation of liver health and function. When administered to cats and dogs with liver disease it has been showed to improve liver values (ALTs/AFTs) along with increasing liver glutathione levels. 1,4,5,6,7,8,9,10
Glutathione is the plus “+” of LiverTrio+. Glutathione is present in all cells in the body. Glutathione is a made from the amino acids glycine, cysteine, and glutamic acid. It is produced by the liver and involved in tissue repair as well as being an integral molecule of the body’s immune system functions. 11
By adding glutathione to LiverTrio+, we are ensuring that during early supplementation, this vital molecule is replenished fast. This should help to a faster recovery of liver function.
By combining S-Adenosylmethionine (SAMe), L- Glutathione, Silybin A+B and Silybin Phosphatidylcholine Complex (SPC), LiverTrio+ provides all those raw ingredients that your pet’s liver will need to heal itself and continue living a long and healthier life.
Tablets are flavored with a combination of bacon and liver flavor for increased palatability.
- Comprehensive combination of SAMe, L- Glutathione and SPC containing Silybin A+B as part of the SPC complex.
- L – Glutathione supplement contributes to faster liver cell recovery by providing an early supply to the glutathione deficient liver until SAMe effects manifest.
- All inclusive weight dosing for dogs and cats.
- Scored tablets, easy to split, for more accurate dosing and monitoring.
- Designed and formulated by a Pharmacist and a Veterinarian.
- Made in the USA and 100% guaranteed.
1- Center SA, Randolph JF, Warner KL, McCabe-McClelland J, Foureman P, Hoffmann WE, Erb HN. The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats. J Vet Intern Med. 2005 May-Jun;19(3):303-14. doi: 10.1892/0891-6640(2005)19[303:teosoc]2.0.co;2. Erratum in: J Vet Intern Med. 2006 Mar-Apr;20(2):465. PMID: 15954543. https://pubmed.ncbi.nlm.nih.gov/15954543/
2- Center SA, Warner KL, Erb HN. Liver glutathione concentrations in dogs and cats with naturally occurring liver disease. Am J Vet Res. 2002 Aug;63(8):1187-97. doi: 10.2460/ajvr.2002.63.1187. PMID: 12171175. https://pubmed.ncbi.nlm.nih.gov/12171175/
3- Selectivity of Silymarin on the Increase of the Glutathione Content in Different Tissues of the Rat, Alfonso Valenzuela, Mónica Aspillaga, Soledad Vial, Ricardo Guerra. https://pubmed.ncbi.nlm.nih.gov/2813578/
4- E. Kilanczyk, J.M. Banales, E. Wunsch, O. Barbier, M.A. Avila, J.M. Mato, M. Milkiewicz, P. Milkiewicz, S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes, Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Volume 1866, Issue 11, 2020, 165895, ISSN 0925-4439, (https://www.sciencedirect.com/science/article/pii/S092544392030243X)
5- C. García-Ruiz, A. Morales, A. Colell, A. Ballesta, J. Rodés, N. Kaplowitz, J.C. Fernandez-Checa Feeding S-adenosyl-l-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes Hepatology., 21 (1995), pp. 207-214, 10.1016/0270-9139(95)90430-1 https://pubmed.ncbi.nlm.nih.gov/7806156/
6- A. Colell, C. García-Ruiz, M. Miranda, E. Ardite, M. Marí, A. Morales, F. Corrales, N. Kaplowitz, J.C. Fernández-Checa Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor Gastroenterology., 115 (1998), pp. 1541-1551, 10.1016/S0016-5085(98)70034-4 https://pubmed.ncbi.nlm.nih.gov/9834283/
7- E. Kilanczyk, J.M. Banales, E. Wunsch, O. Barbier, M.A. Avila, J.M. Mato, M. Milkiewicz, P. Milkiewicz, S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes, Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Volume 1866, Issue 11, 2020, 165895, ISSN 0925-4439, https://doi.org/10.1016/j.bbadis.2020.165895. (https://www.sciencedirect.com/science/article/pii/S092544392030243X)
8- Kenneth Flora, Martin Hahn, Hugo Rosen, Kent Benner, Milk thistle (Silybum marianum) for the therapy of liver disease, The American Journal of Gastroenterology, Volume 93, Issue 2, 1998, Pages 139-143, ISSN 0002-9270, https://doi.org/10.1016/S0002-9270(97)00082-8.(https://www.sciencedirect.com/science/article/pii/S0002927097000828)
9- Au AY, Hasenwinkel JM, Frondoza CG. Hepatoprotective effects of S-adenosylmethionine and silybin on canine hepatocytes in vitro. J Anim Physiol Anim Nutr (Berl). 2013 Apr;97(2):331-41. doi: 10.1111/j.1439-0396.2012.01275.x. Epub 2012 Feb 9. PMID: 22320165. https://pubmed.ncbi.nlm.nih.gov/22320165/
10- Au AY, Hasenwinkel JM, Frondoza CG. Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures. J Vet Pharmacol Ther. 2011 Apr;34(2):120-9. doi: 10.1111/j.1365-2885.2010.01200.x. PMID: 21395602. https://pubmed.ncbi.nlm.nih.gov/21395602/
11- Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684116/
12- Tchantchou, Flaubert et al. ‘S-Adenosylmethionine Mediates Glutathione Efficacy by Increasing Glutathione S-Transferase Activity: Implications for S-Adenosyl Methionine as A Neuroprotective Dietary Supplement’. 1 Jan. 2008 : 323 – 328. https://pubmed.ncbi.nlm.nih.gov/18599958/